(2RS,3RS)-1-(4-chlorophenyl)-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pentan-3-ol

(R*,R*)-(?-b-[(4-chlorophenyl)methyl]-a-(1,1-dimethylethyl)-1H-1,2,4-triazole-1-ethanol

C₁₅H₂₀ClN₃O

White, crystalline solid.

165-166 ℃

0.001 mPa (20 ℃)

1.22 g/ml

In water 26 mg/l (20 ℃). In acetone 110, cyclohexanone 180, dichloromethane 100, hexane 10, xylene 60, methanol 150, propylene glycol 50 (all in g/l, 20 ℃).

Stable for more than 2 years at 20 ℃, and more than 6 months at 50 ℃. Stable to hydrolysis (pH 4-9), and not degraded by u.v. light (pH 7, 10 days).

1.13 ×10^-5 Pa m³ mol^-1 (calc.)

= 3.2

Inhibits gibberellin and sterol biosynthesis, and hence the rate of cell division.

Plant growth regulator taken up into the xylem through the leaves, stems, or roots, and translocated to growing sub-apical meristems. Produces more compact plants and enhances flowering and fruiting.

Used on fruit trees to inhibit vegetative growth and to improve fruit set; on pot-grown ornamentals and flower crops (e.g. chrysanthemums, begonias, freesias, poinsettias and bulbs) to inhibit growth; on rice to increase tillering, reduce lodging, and increase yield; on turf to retard growth; and on grass seed crops to reduce height and prevent lodging. To be applied as a foliar spray, as a soil drench, or by trunk injection. Has some fungicidal activity against mildew and rusts.

Non-phytotoxic, though it intensifies greening. Some spotting has been noted on periwinkle foliage at higher temperatures.

Product analysis by glc or by hplc. Residues determined by tlc.

Acute oral LD50 for male rats 2000, female rats 1300, male mice 490, female mice 1200, guinea pigs 400-600, male rabbits 840, female rabbits 940 mg/kg.

Acute percutaneous LD₅₀ for rats and rabbits >1000 mg/kg. Mild skin irritant; moderate eye irritant (rabbits). Not a skin sensitiser (guinea pigs).

LC₅₀ (4 h) for male rats 4.79, female rats 3.13 mg/l air.

(1 y) for dogs 75 mg/kg daily; (2 y) for rats 250 mg/kg diet.

(JMPR) 0.1 mg/kg b.w. [1988].

WHO (a.i.) III; EPA (formulation) IV

Acute oral LD₅₀ for mallard ducks >7900 mg/kg.

LC₅₀ (96 h) for rainbow trout 27.8 mg/l. NOEC 3.3 mg/l.

LC₅₀ (48 h) 33.2 mg/l.

EC₅₀ (cell volume) for Chlorella fusca 180 umol/l (Pestic. Sci.,47, 337 (1996)).

Soil DT₅₀ 0.5-1.0 y in general; in calcareous clay loam (pH 8.8, 14% o.m.), DT₅₀ <42 d; in coarse sandy loam (pH 6.8, 4% o.m.), DT₅₀ >140 d.

Product analysis by glc or by hplc. Residues determined by tlc.