(2RS,3SR)-1-[3-(2-chlorophenyl)-2,3-epoxy-2-(4-fluorophenyl)propyl]-1H-1,2,4-triazole 

cis-1-[[3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiranyl]methyl]-1H-1,2,4-triazole

C₁₇H₁₃ClFN₃O

Colourless crystals.

136.2^oC

<0.01 mPa (20^oC)

1.384 (room temperature) 

In water 6.63×10^-4 g/100 ml (20^oC). In acetone 14.4, dichloromethane 29.1, heptane 0.04 (all in g/100 ml).

No hydrolysis at pH 5 and pH 7 within 12 days. 

<4.71×10^-4 Pa m³ mol^-1 (calc.)

3.44 (pH 7)

Inhibition of C-14-demethylase in sterol biosynthesis.

Preventive and curative fungicide.

Broad-spectrum fungicide, with preventive and curative action, for control of diseases caused by Ascomycetes, Basidiomycetes, and Deuteromycetes in cereals, sugar beet, peanuts, oilseed rape, and ornamentals, generally at 125 g/ha.

Compatible with morpholines and MBC-derivatives.

Acute oral LD₅₀ for rats >5000 mg/kg.

Acute percutaneous LD₅₀ for rats >2000 mg/kg. Non-irritating to eyes and skin of rabbits.

LC₅₀ (4 h) for rats >5.3 mg/l air. 

(carcinogenicity) for mice 0.81 mg/kg b.w.

0.0032 mg/kg.

R40| R61| R62| N; R51, R53 

Acute oral LD₅₀ for quail >2000 mg/kg. LC50 for quail 5000 mg/kg. 

LC₅₀ (96 h) for trout 2.2-4.6, bluegill sunfish 4.6-6.8 mg/kg.

LC₅₀ (48 h) 8.7 mg/l.

EC₅₀ (72 h) for green algae 2.3 mg/l.

EC₅₀ (14 d) >1000 mg/kg soil. 

There is extensive degradation.

A.i. is readily excreted via faeces. There are no major metabolites, but a high number of minor metabolites was identified. The important metabolic reactions were cleavage of the oxirane ring, hydroxylation of the phenyl rings and conjugation.

Degradation in soil is by microbial activity, DT₅₀ c. 2-3 mo. Koc 957-2647.